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Copyright
© 2007
Connective Tissue Oncology Society
All Rights Reserved
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CTOS 10th
Annual Meeting
November 11 - 13, 2004
2004 Program Chair – Robert Maki
Thursday
11 November 2004 |
| 11:00
am – 5:00 pm
Salon de Saisons
Foyer
1st Floor |
Registration
|
| 11:00am – 5:00 pm
Salon Printemps |
Poster
Set-Up
|
| 1:00 pm – 1:15 pm
Salon de Saisons
1st Floor |
Welcome
and Introductory Remarks
|
| 1:15 pm –
5:00 pm
Salon de Saisons
1st Floor |
Radiology
Symposium |
| |
| 5:00 pm – 6:00 pm
Salon Automne
2nd Floor |
Welcome
Reception
|
| 6:00 pm – 9:00 pm
Salon Ete
2nd Floor |
SARC
Dinner
|
| Friday
12 November 2004 |
| 6:30 am – 5:00 pm
Salon de Saisons Foyer
1st Floor |
Registration
|
| 7:00 am – 8:00 am
Salon de Saisons Foyer
1st Floor |
Continental Breakfast
|
| 7:00 am – 8:00 am
Salon Printemps
1st Floor |
Poster Viewing |
| 7:00 am – 8:00 am
Salon Hiver |
Executive Committee
Meeting
|
| 8:00 am – 9:15
am
Salon de Saisons
1st Floor |
Special Topic:
Patient Selection and Treatment Options for Primary Sarcoma
and Metastases to Spine
Moderators: Dekutoski, Gokoslan, Okuno, Pedersen, Rhines,
Yamada |
|
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1 |
(342)
IMAGE GUIDED INTENSITY MODULATED RADIOTHERAPY (IMRT) WITH
NONINVASIVE IMMOBILIZATION FOR THE HIGH DOSE TREATMENT OF
PRIMARY TUMORS OF THE SPINAL COLUMN
Y Yamada; M Bilsky; M Lovelock; J Zatkcy;
Z Fuks
Memorial Sloan Kettering Cancer Center, New York, New
York, United States |
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|
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| 9:15 am – 9:30 am
Salon de Saisons Foyer
1st Floor |
Coffee Break
|
| 9:30 am – 10:30 am
Salon de Saisons
1st Floor |
Surgery: Staging and
Prognostication
Moderators: Conrad and Grimer |
| |
1 |
(252)
VALIDATION AND ADAPTATION OF A NOMOGRAM FOR PREDICTING SURVIVAL
OF EXTREMITY SOFT TISSUE SARCOMA USING A THREE GRADE SYSTEM
L MARIANI1; R MICELI1;
M KATTAN2; M BRENNAN2;
M COLECCHIA1; M FIORE1;
P CASALI1; * A GRONCHI1
1ISTITUTO NAZIONALE PER LO STUDIO E LA CURA
DEI TUMORI, MILAN, , Italy, 2MEMORIAL
SLOAN KETTERING CANCER CENTER, NEW YORK, NY, United States
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2 |
(296)
MULTICENTRIC EVALUATION OF THE FRENCH SURGICAL SYSTEM IN
SOFT TISSUE SARCOMA (STS)
* E Stoeckle1; * S Bonvalot2;
J Verhaeghe3; F Lejeune5;
J Fraisse4; J Coindre1;
* B Bui1
1Institut Bergonie, Bordeaux, , France,
2Institut Gustave Roussy, Villejuif, ,
France,
3Centre Alexis Vautrin, Nacy, , France,
4Centre George Francois Leclerc, Dijon, , France,
5CHUL Lausanne, Lausanne, , Switzerland
|
| |
3 |
(294)
DECISION MAKING IN ORTHOPAEDIC ONCOLOGY
* R Grimer
Royal Orthopaedic Hospital, Birmingham, , United
Kingdom |
| 10:30 am – 12:00 pm
Salon de Saisons
1st Floor |
Surgery: Local Control
and Outcomes
Moderators: Grimer and Conrad |
| |
1 |
(317)
OUTCOME FOLLOWING PELVIC SARCOMA RESECTION RECONSTRUCTED
WITH SADDLE PROSTHESIS
F Al Jassir1; G Beadel2;
A Griffin2; * R E Turcotte1;
* R S Bell2; J S Wunder2;
M H Isler3
1McGill University Health Center, Montreal,
Quebec, Canada, 2Mount Sinai Hospital,
Toronto, Ontario, Canada, 3Maisonneuve
Rosemont Hospital, Montreal, Quebec, Canada |
| |
2 |
(288)
ADDUCTOR COMPARTMENT SOFT TISSUE SARCOMAS- DOES METHOD OF
TREATMENT AFFECT OUTCOME?
A Pradhan1; Y Cheung1;
* R Grimer2; P Ferguson3;
A Griffin3; S Carter2;
R Tillman2; A Abudu2;
* J Wunder3; * B Bell3
1UNIVERSITY OF BIRMINGHAM MEDICAL SCHOOL,
BIRMINGHAM, WEST MIDLANDS, United Kingdom, 2ROYAL
ORTHOPAEDIC HOSPITAL, BIRMINGHAM, , United Kingdom,
3 MOUNT SINAI HOSPITAL, TORONTO, ONTARIO, Canada
|
| |
3 |
(231)
ENDOPROSTHETIC VS. “CONDYLE-SPARING” INTERCALARY ALLOGRAFTS
FOR DISTAL FEMORAL OSTEOSARCOMA: A COMPARISON OF LONG-TERM
FOLLOW-UP
T B RAPP1; M ZIMEL1;
* E U CONRAD III1
1UNIVERSITY OF WASHINGTON, SEATTLE, WASHINGTON,
United States, 2LOYOLA UNIVERSITY, MAYWOOD,
ILLINOIS, United States |
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4 |
(311)
UNICOMPARTMENTAL OSTEOARTICULAR ALLOGRAFTS OF THE KNEE:
SURVIVAL ANALYSIS AND COMPLICATIONS
M Ayerza; L Muscolo; L Aponte-Tinao;
E Abalo
Italian Hospital of Buenos Aires, Buenos Aires, Buenos
Aires, Argentina |
| |
5 |
(332)
FUNCTIONAL AND ONCOLOGIC OUTCOME AFTER COMBINED ALLOGRAFT
AND TOTAL HIP ARTHROPLASTY RECONSTRUCTION OF LARGE BONY
PELVIC DEFECTS FOLLOWING TUMOUR RESECTION
G P Beadel; A M Griffin; C Ogilvie;
P C Ferguson; J S Wunder; * R S Bell
Mount Sinai Hospital, Toronto, Ontario, Canada |
| 12:00 pm – 1:15 pm
Salon Ete
2nd Floor |
Lunch
|
| 12:00 pm – 1:15 pm
Salon Hiver
2nd Floor |
Board of Directors
Meeting
|
| |
|
|
| 1:15 pm – 3:00 pm
Salon de Saisons
1st Floor
|
Osteosarcoma and Related
Topics
Moderators: Helman and Meyers |
| |
1 |
(261)
POST CHEMOTHERAPY SERUM ALKALINE PHOSPHATASE IS AN INDICATOR
OF CHEMOTHERAPY RESPONSE AND SURVIVAL IN ADULTS TREATED
FOR LOCALISED OSTEOSARCOMA
J Bramer; R Tillman; A Abudu; S Carter;
* R Grimer
Royal Orthopaedic Hospital, Birmingham, West Midlands,
United Kingdom |
| |
2 |
(280)
PET IN OSTEOSARCOMA: THE CORRELATION BETWEEN PERCENT NECROSIS
AND RESPONSE AS SEEN BY PET
* V O Lewis; H A Macapinlac; A Raymond;
* P Lin; * A Yasko; H Choi; * R Benjamin
MD Anderson Cancer Center, Houston, TX, United
States |
| |
3 |
(345)
PREDICTING OUTCOME IN OSTEOSARCOMA USING A GENOME-WIDE APPROACH
T Yan; M Ghert; N Gokgoz; S Eskandarian;
W He; R Parkes; S B Bull; *
R S Bell; * I L Andrulis; * J S Wunder
Samuel Lunenfeld Research Institute and Mount Sinai Hospital,
Toronto, Ontario, Canada |
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4 |
(257)
TREATMENT OF RELAPSED OSTEOSARCOMA AFTER CONTEMPORARY THERAPY:
THE MEMORIAL SLOAN-KETTERING EXPERIENCE
A CHOU; P R MEROLA; Y VYAS; L WEXLER;
R GORLICK; M LAQUAGLIA; J HEALEY;
A HUVOS; * P A MEYERS
MEMORIAL SLOAN KETTERING CANCER CENTER, NEW YORK, NY,
United States |
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5 |
(269)
PRIMARY SPINDLE CELL SARCOMA OF BONE – AN ASSESSMENT OF
OUTCOME
D Peake; * R J Grimer
Royal Orthopaedic Hospital, Birmingham, , United
Kingdom |
| 3:00 pm – 3:45 pm
Salon de Saisons Foyer & Salon
Printemps |
Coffee Break & Poster
Viewing |
| 3:45 pm – 5:00 pm
Salon de Saisons
1st Floor
|
Medical Oncology
Moderators: Patel and LeCesne |
| |
1 |
(347)
ACQUIRED RESISTANCE TO IMATINIB IN PROGRESSIVE GASTROINTESTINAL
STROMAL TUMORS DUE TO MULTIPLE SYNCHRONOUS KINASE MUTATIONS
IN DIFFERENT EXONS OF KIT
E Wardelmann2; N Thomas2;
S Merkelbach-Bruse2; T Pietsch5;
H Biehl4; T Heinicke3;
K Pauls2; * P Hohenberger1
1Section of Surgical Oncology Klinikum Mannheim
University of Heidelberg, Mannheim, , Germany, 2Department
of Pathology University of Bonn Medical Center Germany,
Bonn, , Germany, 3Department of Internal
Medicine University of Bonn Medical Center, Bonn, , Germany,
4Department of Nuclear Medicine Katharinenhospital
Stuttgart, Stuttgart, , Germany, 5Department
of Neuropathology University of Bonn Medical Center, Bonn,
, Germany |
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2 |
(290)
EARLY AND LATE RESISTANCE TO IMATINIB (IM) IN ADVANCED GASTRO-INTESTINAL
STOMAL TUMORS (GIST) ARE PREDICTED BY DIFFERENT PROGNOSTIC
FACTORS: AN ANALYSIS OF THE EORTC-ISG-AGITG RANDOMIZED TRIAL
* M Van Glabbeke1; * J Verweij2;
* P G Casali3; * J Zalcberg4;
* A Le Cesne5; * P Reichardt6;
* J Blay7; M Schlemmer8;
* A T van Oosterom9; * P Hogendoorn10;
K Stoitchkov1; * I R Judson11
1EORTC Data Center, Brussels, , Belgium,
2Erasmus University Medical Center, Rotterdam,
, Netherlands, 3Istituto Tumori, Milano,
, Italy, 4Peter MacCallum Cancer Centre,
Melbourne, , Australia, 5Institut Gustave
Roussy, Villejuif, , France, 6Robert Roessle
Klinik, Berlin, , Germany, 7Centre Leon
Berard, Lyon, , France, 8Klinikum Grosshadern,
Munich, , Germany, 9University Hospital
Gasthuisberg, Leuven, , Belgium, 10University
Medical Center, Leiden, , Netherlands, 11Royal
Marsden Hospital, London, , United Kingdom |
| |
3 |
(263)
A COMPARISON OF PATTERNS OF TUMOR RESPONSE TO MOLECULAR-TARGETED
THERAPY IN GIST AND CHORDOMA
* P Casali; S Stacchiotti; E Fumagalli;
A Messina; C Spreafico; F Crippa; R
Bertulli; F Grosso; P Coco; M Colecchia;
C Piovesan; R Sanfilippo; T Negri;
E Tamborini; A Gronchi
Istituto Nazionale Tumori, Milano, , Italy |
| |
4 |
(227)
DISEASE PROGRESSION IN PATIENTS WITH METASTATIC GASTROINTESTINAL
STROMAL TUMOR (GIST) RECEIVING GLEEVEC (IMATINIB): THE EFFECT
OF DRUG DOSAGE
P Barckett; J Call; P D Josephy; *
N J Scherzer; R Singleton
The Life Raft Group, Wayne, NJ, United
States |
| |
5 |
(250)
DOPAMINE MAY DECREASE NEPHROTOXICITY IN PATIENTS RECEIVING
HIGH-DOSE IFOSFAMIDE
* L J Blakely; * S R Patel; * P Thall;
X Wang; T A Simmons; J L Beach; T L
Armen; * L L Chen; * M A Burgess; *
J C Trent; * R S Benjamin
M D Anderson Cancer Center, Houston, TX, United
States |
| 5:00 pm – 5:30 pm
Salon de Saisons |
Advocacy
Groups
Moderator: Maki |
| 1 |
Sarcoma Foundation of America ,
Jody Cummings |
| 2 |
Sarcoma
Alliance , David Murphy |
| 3 |
Liferaft
Group , Norman Scherzer |
| 5:30 pm – 6:00 pm
Salon de Saisons |
Members
Business Meeting
Moderator: Benjamin |
| 7:00 pm – 8:00 pm
Atrium
1st Floor |
Reception |
| 8:00 pm – 11:00 pm
Pierre de Coubertin
1st Floor |
Dinner |
|
|
|
Saturday
13 November 2004 |
| 6:30 am – 5:00 pm
Salon de Saisons
Foyer
1st Floor |
Registration
|
| 7:00 am – 8:00 am
Salon de Saisons Foyer
1st Floor |
Continental Breakfast
|
| 7:00 am – 8:00 am
Salon Printemps
1st Floor |
Poster Viewing
|
| 8:00 am – 9:00 am
Salon de Saisons
1st Floor
|
Pathology
Moderators: Antonescu and Rosenberg |
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1 |
(344)
AMPLIFICATION AND OVEREXPRESSION OF COPS3 IN OSTEOSARCOMA:
RELATIONSHIP TO P53 MUTATION AND PATIENT OUTCOME
T Yan; N Gokgoz; S Eskandarian; * R
Bell; * I Andrulis; * J Wunder
Mount Sinai Hospital, Toronto, Ontario, Canada
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2 |
(259)
CD56 EXPRESSION IN BONE AND OSTEOBLASTIC NEOPLASIA: A NOVEL
OSTEOBLAST MARKER
D HUGHES; R DEB; D C MANGHAM; V SUMATHI;
* R GRIMER
ROYAL ORTHOPAEDIC HOSPITAL, BIRMINGHAM, , United
Kingdom
YOUNG INVESTIGATOR
AWARD WINNER |
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3 |
(277)
E2F3 OVEREXPRESSION IN SOFT TISSUE SARCOMA DEVELOPMENT
M Scurr1; A Feber1;
J Shipley1; A Fletcher1;
N Dennis1; O Al-Muderis2;
* C Fisher2; * I Judson2;
C Cooper1
1Institute of Cancer Research, London, , United
Kingdom, 2Royal Marsden Hospital, London,
, United Kingdom |
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4 |
(329)
P450 3A AS A MEDIATOR OF CHEMOTHERAPY RESISTANCE IN PATIENTS
WITH SOFT TISSUE SARCOMAS.
* D G Thomas; T J Giordano; M Zalupski;
* S Biermann; * L H Baker
University of Michigan Cancer Center, Ann Arbor, Michigan,
United States |
| 9:00 am – 10:00
am
Salon de Saisons
|
Radiation Oncology
Moderators: O'Sullivan and Robinson |
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1 |
(286)
FIVE YEAR RESULTS OF A RANDOMIZED PHASE III TRIAL OF PRE-OPERATIVE
VS POST-OPERATIVE RADIOTHERAPY IN EXTREMITY SOFT TISSUE
SARCOMA
* B O'Sullivan; * A Davis; * R Turcotte;
R Bell; * J Wunder; C Catton; * R Kandel;
A Hammond; C Freeman; M Isler;
* K Goddard; P Chabot; D Tu; J Pater
Canadian Sarcoma Group and National Cancer Institute
of Canada Clinical Trials Group, Kingston, Ontario, Canada
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2 |
(234)
MORTALITY AFTER APPARENT CURE OF SOFT TISSUE SARCOMA USING
COMBINED MODALITY THERAPY
* M T Ballo; G K Zagars; S S Strom;
* P W Pisters; * S R Patel; * B W Feig;
* J N Cormier; K K Hunt; * R E Pollock;
* R S Benjamin
M D Anderson Cancer Center, Houston, TX, United
States |
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3 |
(308)
INTENSITY MODULATED RADIATION THERAPY (IMRT) FOR PRIMARY
SOFT TISSUE SARCOMA OF THE EXTREMITY: PRELIMINARY RESULTS
K M Alektiar; L Hong; M F Brennan;
S Singer
Memorial Sloan Kettering Cancer Center, New York, NY,
United States |
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4 |
(327)
POST-IRRADIATION RECOVERY OF GROWTH PLATE FUNCTION IS DRIVEN
BY EXPANSIONS OF REGENERATIVE CLONES
J A Horton; B S Margulies; J A Strauss;
J A Spadaro; * T A Damron
SUNY Upstate Medical University, Syracuse, NY, United
States |
| 10:00am – 10:15
am
Salon de Saisons
Foyer & Salon Printemps |
Coffee Break and Poster
Viewing
|
| 10:15 am – 11:15
am
Salon de Saisons |
Nina Axelrad Lecture:
Cytogenetic
Insights in Mesenchymal Tumors
J. Fletcher |
| 11:15 am –
12:45 pm
Salon de Saisons
|
Biology
Part I: Basic Science Models and Molecular Profiles
Moderators: Wunder and Ladanyi |
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1 |
(281)
HIGH EXPRESSION OF EZRIN, A DETERMINANT OF METASTATIC BEHAVIOR,
IN EWING'S SARCOMA (ES)
K Krishnan1; G Khanna1;
S Hewitt1; * C Khanna1;
* L Helman1
1National Institutes of Health, Bethesda,
Maryland, United States, 2NATIONAL INSTITUTES
OF HEALTH, BETHESDA, MARYLAND, United States, 3UNIVERSITY
OF MINNESOTA, MINNEAPOLIS, MINNESOTA, United States |
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2 |
(339)
CONDITIONAL KNOCKOUT OF P53 IN MESENCHYMAL CELLS OF MICE
RESULTS IN OSTEOSARCOMAS
* P P Lin; F Jin; G Lozano
MD Anderson Cancer Center, Houston, TX, United
States |
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3 |
(351)
TRANSFORMATION OF MESENCHYMAL STEM CELLS BY THE RETROVIRUS-MEDIATED
GENE TRANSFER
Y Shima1; T Okamoto1;
T Ishibe1; K Nishijo1;
T Aoyama2; T Nakayama1;
T Nakamura1; J Toguchida2
1Department of Orthopaedic Surgery Kyoto University,
Kyoto, , Japan, 2Institute for Frontier
Medical Sciences Kyoto University, Kyoto, , Japan |
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4 |
(242)
MOLECULAR PROFILING OF GIANT CELL TUMOURS
D M THOMAS; T TALARICO; P CHOONG; J
SLAVIN; S SCHLICHT; I DICKINSON; M
TRIVETT; P SIMMONS; G ATKINS; D FINDLAY
PETER MACCALLUM CANCER CENTRE, MELBOURNE, VICTORIA, Australia
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5 |
(313)
MOLECULAR ANALYSIS OF SPORADIC AND NEUROFIBROMATOSIS TYPE
1 (NF1)-ASSOCIATED MALIGNANT PERIPHERAL NERVE SHEATH TUMORS
M Watson; A Perry; * D H Gutmann
Washington University, St. Louis, MO, United
States |
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6 |
(271)
GENE EXPRESSION PROFILES RELATE TO GENE FUSION TYPE AND
METASTASIS IN SYNOVIAL SARCOMA
J Fernebro1; P Francis1;
P Edén2; I Panagopoulos3;
F Mertens3; M Åkerman4;
N Mandahl3; M Nilbert1
1Department of Oncology, Lund University Hospital,
, Sweden, 2Department of Theoretical Physics,
Lund University, , Sweden, 3Department
of Clinical Genetics, Lund University Hospital, , Sweden,
4Department of Pathology, Lund University
Hospital, , Sweden |
| 12:45 pm – 1:45
pm
Salon Ete
2nd Floor |
|
Lunch
|
| 1:45 pm – 2:45 pm
Salon de Saisons
|
Biology Part II: Translation:
Bench to Clinic
Moderators: Wunder and Ladanyi |
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1 |
(256)
17-AAG INHIBITS SYNOVIAL SARCOMA CELL GROWTH IN VITRO
J Terry; S Liu; J Lubieniecka; * T
O Nielsen
University of British Columbia, Vancouver, BC, Canada
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2 |
(350)
FIBROBLAST GROWTH FACTOR SIGNALS AS POTENTIAL MOLECULAR
TARGETS IN SYNOVIAL SARCOMA
T Ishibe1; T Nakayama1;
T Okamoto1; T Aoyama2;
K Nishijo1; S Nagayama3;
T Nakamura1; J Toguchida2
1Department of Orthopaedic Surgery Kyoto University,
Kyoto, , Japan, 2Institute for Frontier
Medical Sciences Kyoto University, Kyoto, , Japan,
3Department of Surgery Kyoto University, Kyoto,
, Japan
YOUNG INVESTIGATOR
AWARD WINNER |
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3 |
(338)
HEDGEHOG SIGNALING REGULATES PROLIFERATION IN CHONDROSARCOMA:
IMPLICATIONS FOR NOVEL THERAPY
D Tiet1; S Hopyan2;
P Nadesan1; B A Alman1;
* J S Wunder2
1Hospital for Sick Children, Toronto, , Canada,
2University Musculoskeletal Oncology Unit
at Mount Sinai Hospital, Toronto, , Canada
|
| 2:45 pm – 3:00 pm
Salon de Saisons Foyer & Salon Printemps |
Coffee Break and
Poster Viewing
|
| 3:00 pm – 3:30 pm
Salon de Saisons |
Special Topic: Molecular
Analysis of Sarcomas
Discussants: Ladanyi, Maki, Labelle, Squire |
| 3:30 pm – 3:45 pm
Salon de Saisons |
1.
Sarcomas with Aberrant Transcription Factors-Biology and
Expression Profiling
Speaker: Ladanyi |
| 3:45 pm –
4:00 pm
Salon
de Saisons
|
2. Extraskeletal
Myxoid Chondrosarcoma: Two Views of the Same Tumor
Speaker: Maki: Clinical Aspects |
| |
(302)
CASE REPORT: EXTRASKELETAL MYXOID CHONDROSARCOMA (EMC)
* R G Maki
Memorial Sloan Kettering Cancer Center, New York, NY,
United States |
| |
|
|
| 4:00 pm – 4:30 pm
Salon de Saisons |
3.
Extraskeletal myxoid chondrosarcoma: two views of the same
tumor
Speaker: Labelle: Functional analysis of the EWS/NOR1
fusion protein expressed in extraskeletal myxoid chondrosarcomas
|
| 4:30 pm – 5:00 pm
Salon de Saisons |
4.
Molecular cytogenetics of osteosarcoma
Speaker: Zielenska |
| 5:15 pm – 5:45 pm
Salon de Saisons |
Collaborative Studies
Discussion
Moderator: Maki |
| 5:45 pm – 6:00 pmSalon
de Saisons |
Closing Remarks
Moderator: Maki |
|
|
