2002 CTOS Annual Meeting Posters — Medical Oncology

IN VITRO CHEMOSENSITIVITY OF HUMAN SOFT TISSUE SARCOMA TISSUE
[Abstract ID: 63]

Category: Medical Oncology

Authors: Hideo Morioka¹

Author Institutions: ¹Department of Orthopaedic Surgery School of Medicine Keio University, Tokyo, Japan; ²Department of Surgery School of Medicine Keio University, Tokyo, Japan

Presenter: Hideo Morioka
morioka@sc.itc.keio.ac.jp

Correspondent: Hideo Morioka
morioka@sc.itc.keio.ac.jp
Tokyo Tokyo Japan 160-8582
Ph: +81-3-5363-3812
Fax: +81-3-3353-6597

Objectives: The Histoculture Drug Response Assay (HDRA) is an in vitro chemosensitivity test that has a high correlation with clinical response, the usefulness of which has been reported in various kinds of solid tumors. In this study, in order to investigate the variation in chemosensitivity in STS, fresh biopsy or surgical samples of STS were tested using the HDRA methods.

Methods: Eighty samples of fresh human STS were obtained during either the biopsy or surgical removal at Keio University Hospital in Japan between 1997 and 2001. As anti-tumor drugs, cisplatin (CDDP), doxorubicin (ADM), pirarubicin (THP), 4-hydroxy-ifosfamide (4-H-IFO) and etoposide (VP-16) were used. HDRA was performed according to the method previously reported.

Results: Drug sensitivity testing by HDRA showed that two drugs, ADM and THP, had a significantly higher inhibitory rate than CDDP, IFOS, or VP-16 in the eighty soft tissue sarcomas tested. Depending on the morphological type, spindle cell sarcomas were sensitive to THP, which showed significantly higher inhibition rates than CDDP, IFOS, or VP-16. Small round cell sarcomas were relatively sensitive to all of the drugs tested. However the drug sensitivity of pleomorphic cell sarcoma was low except for ADM and THP, while its sensitivity to THP was higher than about 70%.

Conclusions: Depending on the morphological type, STS showed various chemosensitivity in HDRA. However, there are numerous other soft tissue sarcomas that do not belong to these categories; drug sensitivity testing in each of them and the devising of individualized treatment strategies seems necessary to improve the therapeutic outcome.