2002 CTOS
Annual Meeting Oral Presentations — Surgery
DESMOID
TUMORS. A CLINICAL REVIEW OF 30 PATIENTS WITH MORE THAN 20 YEARS
FOLLOW-UP
[Abstract
ID: 50]
Category:
Surgery
Presentation:
Young Investigator
Authors: Mikael
Dalén1, Peter Bergh1, Björn Gunterberg1
Author Institutions:
1Department of Orthopaedic Surgery, Gothenburg, Sweden
Presenter: Mikael
Dalén
Email: mikaeldalen@hotmail.com
Correspondent:
Mikael Dalén
mikaeldalen@hotmail.com
Gothenburg Sweden SE-413 45
Ph: 0046 31 3424433
Fax: 0046 31 825599
Objectives: Thirty
patients with desmoid tumors treated at our department with more
than 20 years follow-up (mean 28 years) were reviewed.
Methods: Twenty patients were women, 10 were men with a mean
age of 39 years. The tumors were located in the abdominal wall (7),
upper extremity (6), lower extremity (6), back (5), thoracic wall
(4), head-and-neck region (1). One patient presented with multifocal
tumors. Largest mean tumor diameter was 7 cm. Twenty-nine patients
had surgery, 3 of which had additional radiotherapy. One patient
received adjuvant antioestrogen therapy (Tamoxifen®). The surgical
margins were intralesional in 6 tumors, marginal in 13 tumors and
wide/compartmental in 10 tumors. One patient had radiotherapy alone.
Results: Two patients died of non-tumor related causes. Sixteen
patients were continuously disease free (CDF). At follow-up, all
patients but 1 were free of symptoms. Thirteen patients had no evidence
of disease (NED), two of which were primarily operated with debulking
surgery. Six patients had mild to moderate post-treatment symptoms.
One patient was alive with disease (AWD). She was operated on three
times and had additional radiotherapy as well as antioestrogen therapy.
At follow-up the patient had disabling symptoms. The overall recurrence
rate was 44%. A less tendency for recurrence was evident in patients
operated with a wide or compartmental excision. Three tumors disappeard
spontaneously.
Conclusions: Patients operated with a wide or compartmental
margin had the least risk to develop recurrent tumor. Observation
alone might be considered in selected cases.
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