Posters— Surgical Treatment of Sarcomas

AGGRESSIVE FIBROMATOSIS. A RETROSPECTIVE STUDY OF 72 PATIENTS

Sørensen A, Keller J, Nielsen OS, Jensen OM. (Centre for Bone and Soft Tissue Sarcomas, University Hospital of Aarhus, Aarhus, DK-8000)

Introduction: Aggressive fibromatosis (or desmoid) has a high recurrence rate as a result of a strong infiltrative growth pattern. The purpose of this study was to evaluate outcome and influence of possible prognostic factors following surgical treatment of aggressive fibromatosis, and in an immunohistochemical project to evaluate expression of estrogen receptors.

Materials and methods: 72 primary tumours treated in the period January 1970 to September 1998 were analysed; 19 men and 53 women. Median age was 31 (1 month-77years) years. 50 patients had an extra abdominal tumour and 22 an abdominal. Median tumour size was 4 (1-27) cm. Log rank and Cox regression analyses were used for statistical analyses. For immunohistochemical determination deparaffinized slides were used.

Results: The overall and relapse-free 5-year survival were 98% and 73%, respectively. A univariate analysis identified age, tumour size and surgical compartmentalisation as prognostic factors for local recurrence. Furthermore radiotherapy was found to have an effect in extra abdominal tumours. A multivariate analysis identified age >31 years, tumour size £4 cm and intracompartmental location as independent positive prognostic factors for local recurrence. No tumours expressed estrogen receptors.

Conclusions: Aggressive fibromatosis has a high local recurrence rate. Age, tumour size and surgical compartmentalisation seem to affect the local recurrence rate. The tumour do not express estrogen receptors.