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Connective Tissue Oncology Society
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PROGNOSTIC FACTORS IN SOFT TISSUE SARCOMAS (STS)

1Stefanovski PD, 2De Paoli A, 1Buonadonna A, 3Bidoli E, 1Frustaci S. 1Division of Medical Oncology, 2Division of Radiation Therapy, 3Division of Epidemiology, Centro di Riferimento Oncologico, Aviano, Italy.

Aim of the study: To identify specific independent prognostic factors for overall survival (OS), local recurrence (LR), distant recurrence (DR) and post-metastasis survival (PMS) in STS pts.

Patients & Methods: Retrospective uni- & multivariate analysis of a prospective data base for 444 pts. with primary STS with different localizations, treated and followed-up in our Institute from January 1985 until January 1997. We correlated: age, sex, performance status (PS)(ECOG/WHO), hemoglobin value (Hgb), size, histology, grade (Broders/TNM), TNM stage (UICC/AJCC), local relapse and distant metastasis (DM).

Results: Median age of the patients was 53 years (range 10 to 95) with median follow-up time of 35,6 months.

UNIVARIATE & MULTIVARIATE ANALYSIS
variable
OS
LR
DR
PMS
  p p° p p° p p° p p°
Age (>50y)° 0,005 0,001     0,02 0,04 0,03 0,02
Hgb (<10g/dL) 0,001 0,04            
PS (>2°) 0,0001 0,0001            
Grade (high)° 0,0001 0,004 0,05 0,01 0,0001 0,0001    
Size (>5cm)° 0,0001 0,0006     0,0003 0,01    
Stage (advanced)° 0,0001 0,0001 0,03 0,02°° 0,0001 0,0001    
DM 0,0001 0,0001            
Histology     0,02   0,004 0,03°°°    
Site         0,03      
Trunk   0,002            
Head & Neck   0,02           0,04
Retriperitoneal   0,003            
Visceral   0,01            
Uterinal                
Leiuomyosarcoma   0,04       0,002    
SinovialSarcoma   0,05           0,02
NOS STS   0,03           0,02

Conclusions: 1) Different prognostic factors are significant for different end points in STS pts; 2) UICC/AJCC TNM staging system for STS has stronger prognostic significance for the end points of OS and DR compared to those of LR and is not significant for PMS; 3) Local relapse has no prognostic value for OS, DR, and PMS; 4) Particular histologic subtypes and localizations have negative prognostic value for OS, DR, and PMS which could be of importance in future treatment decisions.

 

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